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. Author manuscript; available in PMC: 2024 Apr 11.
Published in final edited form as: J Control Release. 2023 Jul 31;361:53–63. doi: 10.1016/j.jconrel.2023.07.040

Fig. 6.

Fig. 6.

Representative evaluation results of comparisons between the AI-PBPK model predictions versus experimentally measured pharmacokinetic profiles of NPs in tumors. NP concentration in tumor (%ID/g) predicted from the PBPK model with optimized parameters (dashed line) compared to the observed NPs amount in tumor from experimental data (black closed circles) for 15 randomly selected NPs from the study of (A-B) Cabral et al. (2011) [65], (C-E) Guo et al. (2013) [66], (F-G) Sumitani et al. (2013) [67], (G-M) Bae et al. (2007) [68], (N) Bibby et al. (2005) [69] and (O) Bae et al. (2005) [70]. Tumor tissue concentrations as presented in the y-axis are expressed in the units of percent of the injected dose (%ID/g) according to units used in the original articles.