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. Author manuscript; available in PMC: 2024 Apr 11.
Published in final edited form as: J Control Release. 2023 Jul 31;361:53–63. doi: 10.1016/j.jconrel.2023.07.040

Table 2:

Five-fold cross-validation and testing results for tumor-related parameters using different machine learning and deep learning models

KTRES_rel KTRES_n KTRES_max KTRES_50
Model 5-fold CV Test 5-fold CV Test 5-fold CV Test 5-fold CV Test
LR
 R2 −0.08 ± 0.16 0.04 −0.03 ± 0.03 0.03 −0.04 ± 0.18 0.06 −0.04 ± 0.04 0.06
 RMSE 2.05 ± 0.45 2.49 2.25 ± 0.15 2.32 3.59 ± 1.03 2.25 33.37 ± 4.86 35.28
SVR
 R2 −0.05 ± 0.06 −0.01 −0.08 ± 0.06 −0.05 −0.02 ± 0.01 0.001 −0.18 ± 0.15 −0.02
 RMSE 2.03 ± 0.48 2.54 2.29 ± 0.19 2.4 3.62 ± 1.16 2.31 35.4 ± 5.16 36.8
RF
 R2 0.03 ± 0.13 0.18 0.138 ± 0.08 0.4 0.035 ± 0.28 0.43 0.11 ± 0.06 0.16
 RMSE 1.96 ± 0.49 2.3 2.05 ± 0.07 1.83 3.37 ± 1.05 1.75 31.9 ± 5.33 30.68
XGBoost
 R2 0.001 ± 0.13 0.13 0.085 ± 0.103 0.07 0.07 ± 0.24 0.36 0.079 ± 0.05 0.15
 RMSE 1.99 ± 0.53 2.37 2.1 ± 0.11 2.27 3.35 ± 1.19 1.84 32.7 ± 4.74 30.78
LightGBM
 R2 0.045 ± 0.09 0.2 0.025 ± 0.09 0.11 0.15 ± 0.43 0.31 0.131 ± 0.07 0.16
 RMSE 2.03 ± 0.49 2.28 2.17 ± 0.147 2.22 3.58 ± 1.00 1.92 31.7 ± 4.79 30.6
DNN
 R2 0.67 ± 0.34 0.47 0.47 ± 0.23 0.53 0.44 ± 0.29 0.91 0.22 ± 0.37 0.23
 RMSE 0.74 ± 0.46 1.85 1.51 ± 0.34 1.6 2.65 ± 1.47 0.71 28.6 ± 6.52 32.15

Abbreviations: LR, linear regression; RF, random forest; SVM, regular support vector machine; DNN, deep learning neural network; CV, cross-validation; XGBoost, eXtreme Gradient Boosting; LightGBM, light gradient-boosting machine.