Table 2:

Characteristics of KTR with allograft rejection in the context of ICI [14, 15, 17, 18].

Risk of rejection	Up to 48%
Diagnosis	Rise in serum creatinine and kidney biopsy
Median time to graft rejection	3 weeks
Histology of rejected allograft	TCMR or mixed TCMR and ABMR
Response to treatment	Poor with up to 70% graft loss
Risk factors	Low-dose corticosteroids, history of graft rejection, anti-PD-1 treatment or combination therapy
Factors associated with lower risk of rejection	mTOR and at least two immunosuppressants at time of ICI initiation

KTR: kidney transplant recipients, TCMR: T cell-mediated rejection, ABMR: antibody-mediated rejection. PD-1: programmed cell death-1, mTOR: mammalian target of rapamycin