Fig 4. Live-virus neutralization activity against ancestral D614G and BA.5 SARS-CoV-2 variant after booster vaccination.

Neutralizing titer (FRNT₅₀) against ancestral D614G (A&B) and Omicron BA.5 (C&D) at BL and post-vaccine booster. A&C show titer at BL, W2 and W24 post-boost for D614G (A) and BA.5 (C). Fold-change of the GMT is indicated at the bottom of each graph. The color-coded dots and bold lines represent the GMT at each time point. Recorded BTI between W2 and W24 are depicted with red lines. Statistical comparisons were performed using a Friedman test with Dunn’s correction. B&D show fold-change in neutralizing titer against D614G (B) and BA.5 (D) between BL and W2 in each study arm. Bars represent median fold-change. A Kruskal-Wallis test with Dunn’s correction was used to compare different arm groups. (E) Comparison of the neutralizing titer (FRNT₅₀) against D614G (left panel) and BA.5 (right panel) between study arms at W24. Bars represent GMT. Statistical comparisons were performed using a Kruskal-Wallis test with Dunn’s correction.