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. 2023 Nov 30;38(6):1140–1148. doi: 10.1038/s41433-023-02848-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A total of 132 patients were screened and, after 38 withdrawals, a total of 94 patients were randomized to each of the treatment groups, Arm 1 (umedaptanib pegol monotherapy), Arm 2 (umedaptanib pegol + aflibercept combination therapy), and Arm 3 (aflibercept monotherapy), and subjected to clinical trials.