Figure 1.

Generalized paramyxovirus life cycle. (1) Attachment of the viral particle, mediated by the attachment protein. (2) Fusion between the viral and a cellular membrane to release the ribonucleoprotein complex containing the negative sensed genome into the cytosol. Transcription (3a) of viral messenger RNA (mRNA) is promoted by the viral polymerase complex within viral-induced inclusion bodies, followed by translation (3b) in the cytosol, and replication of viral genomes within intracytoplasmic inclusion bodies (3c). (4) Viral proteins and encapsidated genome are transported to sites of assembly and budding occurs from the plasma membrane.