. 1998 Oct;72(10):7815–7821. doi: 10.1128/jvi.72.10.7815-7821.1998

TABLE 1.

Total splenic CD3⁺ and CD8⁺ lymphocyte number and splenic CTL activity in 129SV/EV and IFN-γ R^−/− mice infected with LCMV

Expt	Mouse strain	n^a	No. of splenocytes/spleen								Splenic CTL activity
			Day 0 p.i.		Days 7–8 p.i.		Days 10–11 p.i.		Days 13–15 p.i.		Day 0 p.i.		Days 7–8 p.i.		Days 10–11 p.i.		Days 13–15 p.i.
			CD3⁺ (10⁷)	CD3⁺ CD8⁺ (10⁷)	CD3⁺ (10⁷)	CD3⁺ CD8⁺ (10⁷)	CD3⁺ (10⁷)	CD3⁺ CD8⁺ (10⁷)	CD3⁺ (10⁷)	CD3⁺ CD8⁺ (10⁷)	% Specific lysis^c	Total LU^d	% Specific lysis	Total LU	% Specific lysis	Total LU	% Specific lysis	Total LU
1	129	2	5.8	0.6	9.5	0.6	14.3	2.8	8.3	1.0	7	<1	38	108	64	551	30	35
	IFN-γ R^−/−	2	6.2	0.5	10.4	1.2	11.3	2.4	15.3	2.0	6	<1	60	256	69	339	58	341
2	129	2	3.9	0.6	4.7	0.8	2.3	1.9	3.6	1.5	−2	<1	28	111	39	199	21	75
	IFN-γ R^−/−	2	3.2	0.7	4.6	1.1	3.4	1.9	4.9	2.0	−3	<1	29	171	43	222	27	149
3	129	4	ND^b	ND	5.7	2.0	ND	ND	4.0	1.8	ND	ND	17	73	ND	ND	18	78
	IFN-γ R^−/−	3	ND	ND	2.5	1.2	ND	ND	3.9	3.0	ND	ND	13	75	ND	ND	30	396
4	129	2	2.9	0.6	ND	ND	3.5	2.4	2.5	1.6	−1	<1	ND	ND	37	173	24	48
	IFN-γ R^−/−	2	2.1	1.5	ND	ND	2.9	1.4	4.7	3.6	−2	<1	ND	ND	39	196	34	233
5	129	2	ND	ND	1.7	1.3	ND	ND	ND	ND	ND	ND	50	175	ND	ND	ND	ND
	IFN-γ R^−/−	2	ND	ND	1.7	0.9	1.5	1.1	4.3	3.0	ND	ND	31	111	36	155	35	181

Number of mice per experiment. The results for the 129 mice are from pooled spleens. The results for the IFN-γ R^−/− mice are averages of individual mice.

ND, not done.

At effector-to-target cell ratio of 100:1 (see Materials and Methods).

See Materials and Methods.