Fig. 5.

Neuroregenerative properties of AC102. (A) Effects of varying concentrations of AC102 on neurite outgrowth in HT22 cells. Shown are mean ± SEM (n = 10). Mixed effects analysis and Fisher’s LSD test for comparison of AC102-treated groups against vehicle (**P ≤ 0.01, ***P ≤ 0.001). (B) Regenerative effect of AC102 of neurite outgrowth in a rotenone damage model, in which different concentrations of AC102 were applied to cells for 24 h after a 2 h damage with rotenone. Shown are mean ± SEM (n = 6). One-sided paired t test for damage model (^###P ≤ 0.001). Repeated measures one-way ANOVA and Fisher’s LSD test for comparison of AC102-treated groups against damage alone (*P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001). (C) Representative images from selected groups of b. Cells and neurites are marked with red and black asterisks, respectively. (Scale bar, 100 µm.)