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. Author manuscript; available in PMC: 2024 Aug 21.
Published in final edited form as: Chem Res Toxicol. 2023 Jul 21;36(8):1409–1418. doi: 10.1021/acs.chemrestox.3c00141

Table 1.

Quantitative Analysis of Genomic EB-GII Adducts (Adducts/109 nucleotides) in Tissues of Rats Treated with BD-d6a,b

Exposure Level (ppm BD-d6)
Tissue Source All 0 0.3 0.5 3
Liver Exogenous 0.21c ± 3.83 ND 0.19c ± 1.76 0.25 ± 2.23 0.93 ± 2.90
Endogenous ND ND 0.10c ± 1.64 ND ND
Lung Exogenous 0.18c ± 4.20 ND 0.08c ± 1.02 0.18c ± 1.81 1.24 ± 1.21
Endogenous ND ND ND ND ND
Heart Exogenous 0.22c ± 4.03 ND 0.14c ± 1.16 0.15c ± 1.10 1.75 ± 1.26
Endogenous 0.10c ± 1.70 0.16c ± 1.19 ND 0.10c ± 1.65 0.14c ± 1.09
Pancreas Exogenous 0.80 ± 4.69 ND 0.88 ± 1.20 1.02 ± 1.38 5.25 ± 1.36
Endogenous ND 0.11c ± 1.86 ND ND ND
a

Results are shown As GM ± GSD

b

ND indicates not detectable above detection limit of 0.078 adducts/109 nucleotides

c

indicates a value reported above detection limit of 0.078 adducts/109 nucleotides but less than quantitation limit of 0.237 adducts/109 nucleotides