Table 1.
Quantitative Analysis of Genomic EB-GII Adducts (Adducts/109 nucleotides) in Tissues of Rats Treated with BD-d6a,b
Exposure Level (ppm BD-d6) | ||||||
---|---|---|---|---|---|---|
Tissue | Source | All | 0 | 0.3 | 0.5 | 3 |
Liver | Exogenous | 0.21c ± 3.83 | ND | 0.19c ± 1.76 | 0.25 ± 2.23 | 0.93 ± 2.90 |
Endogenous | ND | ND | 0.10c ± 1.64 | ND | ND | |
Lung | Exogenous | 0.18c ± 4.20 | ND | 0.08c ± 1.02 | 0.18c ± 1.81 | 1.24 ± 1.21 |
Endogenous | ND | ND | ND | ND | ND | |
Heart | Exogenous | 0.22c ± 4.03 | ND | 0.14c ± 1.16 | 0.15c ± 1.10 | 1.75 ± 1.26 |
Endogenous | 0.10c ± 1.70 | 0.16c ± 1.19 | ND | 0.10c ± 1.65 | 0.14c ± 1.09 | |
Pancreas | Exogenous | 0.80 ± 4.69 | ND | 0.88 ± 1.20 | 1.02 ± 1.38 | 5.25 ± 1.36 |
Endogenous | ND | 0.11c ± 1.86 | ND | ND | ND |
Results are shown As GM ± GSD
ND indicates not detectable above detection limit of 0.078 adducts/109 nucleotides
indicates a value reported above detection limit of 0.078 adducts/109 nucleotides but less than quantitation limit of 0.237 adducts/109 nucleotides