Table 3.
Associations Between the Plasma AD Markers and Infarcts
| Plasma levels (per SD increase) | Infarcts, OR (95% CI), adjusted P value | Lacunar infarcts, OR (95% CI), P value | Cortical infarcts, OR (95% CI), P value |
|---|---|---|---|
| Model 1 | |||
| Aβ42/40 | 1.18 (0.86–1.63), P=0.827 | 1.30 (0.84–2.02), P=0.240 | 1.04 (0.85–1.26), P=0.723 |
| p‐tau181 | 1.16 (0.96–1.40), P=0.729 | 1.22 (1.00–1.50), P=0.055 | 1.17 (0.92–1.50), P=0.202 |
| NfL | 1.42 (1.13–1.78), P=0.039* | 1.36 (1.06–1.73), P=0.014* | 1.58 (1.20–2.08), P=0.001* |
| GFAP | 0.98 (0.79–1.21), P=0.827 | 0.86 (0.68–1.10), P=0.224 | 1.45 (1.09–1.92), P=0.010* |
| Model 2 | |||
| Aβ42/40 | 1.17 (0.83–1.64), P=0.785 | 1.27 (0.82–1.95), P=0.288 | 1.01 (0.84–1.23), P=0.883 |
| p‐tau181 | 1.13 (0.93–1.37), P=0.785 | 1.19 (0.97–1.47), P=0.101 | 1.13 (0.88–1.45), P=0.342 |
| NfL | 1.41 (1.12–1.79), P=0.052 | 1.36 (1.05–1.74), P=0.018* | 1.54 (1.16–2.03), P=0.003* |
| GFAP | 1.03 (0.82–1.30), P=0.785 | 0.87 (0.68–1.13), P=0.297 | 1.56 (1.16–2.10), P=0.003* |
Model 1 is adjusted for age, sex, and education. Model 2 adds diabetes, hypertension, smoking status, and alcohol use. P values are adjusted using the Hommel method. Aβ indicates amyloid‐beta; AD, Alzheimer's disease; GFAP, glial fibrillary acidic protein; NfL, neurofilament light; OR, odds ratio; and p‐tau, phosphorylated tau.
*
P values shown are corrected using the Hommel method, with P<0.05 denoting significance.