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. 2020 Dec 14;148(4):464–476. doi: 10.1017/S0031182020002346

Fig. 4.

Fig. 4.

Lesions and parasite detection in HE staining and specific labelling by IHC from tissues of mice infected with different strains of T. gondii. (A) and (E) Liver from a G3 (genotype BrI) mouse euthanized at 9 dpi. Focus of necrotizing mononuclear hepatitis (A, circle, HE, bar 100 μm), large number of immunolabelled tachyzoites and a moderately large cyst (arrow) within lesions (E, IHC, bar 100 μm). (B) and (F) Kidney from a G3 mouse euthanized at 9 dpi, small mononuclear focus of nephritis (B, circle, HE, bar 100 μm), and large number of immunolabelled T. gondii tachyzoites and cysts associated or not (arrow) with lesions (F, IHC, bar 100 μm). (C) and (G) Lungs from mice from G4 (genotype BrIII) euthanized at 14 dpi. Large focus of necrotizing interstitial pneumonia with mild central necrosis (C, HE, bar 100 μm), immunolabelled T. gondii cysts (arrow) not associated with lesions (G, IHC, bar 50 μm). (D) and (H) Brains from G4 mice euthanized at 14 dpi. Small mononuclear perivascular cuffs (D, circle, HE, bar 100 μm), immunolabelled T. gondii cysts and single tachyzoite not associated with lesions (H, IHC, bar 50 μm).