Table 1.
CBi/L | CBi+ | |||
---|---|---|---|---|
Males | Females | Males | Females | |
Treatment | Variable: nAP2 | |||
Control | 6.5 (2–17)a | 2.0 (0–5)a | 13.5 (9–19)a | 22.0 (10–27)a |
ABZ | 7.0 (3–8)a | 1.5 (0–3)a | 13.5 (10–17)a | 8.0 (3–17)a |
S4A | 6.5 (1–8)a | 2.0 (0–10)a | 19.5 (13–24)a | 17.0 (14–20)a |
S10A | 7.0 (3–14)a | 0 (0–3)a | 15.0 (5–23)a | 21.0 (20–23)a |
Variable: Ff3 | ||||
Control | 29 ± 15.2 | 344 | 50 ± 25.0 | 46 ± 16.6 |
ABZ | – | – | – | – |
S4A | – | – | – | – |
S10A | – | – | – | – |
nAP, total number of intestinal adult parasites; Ff, T. spiralis female fecundity.
nAP differences among treatments within genotype and sex were evaluated with the nonparametric Kruskal–Wallis test followed by Dunn's test for between-groups comparison (nAP).
For each column, differences between groups not sharing the same superscript are significant at the 0.05 level.
Mice were treated on days 5, 6 and 7 p-i and sacrificed two days after the administration of the last dose (9 days p-i).
Median (range).
Mean ± s.e.m.
Only one female recovered.