Table.

Correlation of Outcome Measures at Week 26

	Change in retinal layer thickness						Patient-reported outcome
	pRNFLa	mRNFL	mGCIPL	mINOPL	mONL	mPRRPE	NEI-VFQ
pRNFL thickness change, µm	1	0.63	0.76	0.04	−0.28	−0.25	0.15
mGCIPL thickness change, µm	0.76	0.73	1	0.23	−0.23	−0.18	0.08
LCLA, 2.5% Sloan chart score	0.57	0.37	0.53	−0.04	−0.12	−0.28	0.39
CS, log	0.56	0.11	0.42	−0.09	−0.07	−0.19	0.42
HCVA, ETDRS chart score	0.48	0.15	0.25	−0.07	−0.17	−0.24	0.60
Visual field MD, dB	−0.46	−0.35	−0.25	−0.05	0.05	0.31	−0.34
VEP P100 amplitude, µV	0.35	0.24	0.35	0.04	−0.04	−0.15	0.31
VEP P100 peak time, ms	−0.31	−0.09	−0.11	0.13	0.34	0.18	−0.07

Abbreviations: CS = contrast sensitivity; HCVA = high-contrast visual acuity; LCLA = low-contrast letter acuity; MD = mean defect; mGCIPL = macular ganglion cell and inner plexiform layer; mINOPL = macular inner nuclear and outer plexiform layer; mONL = macular outer nuclear layer; mPRRPE = macular photoreceptor layer and retinal pigment epithelium; mRNFL = macular retinal nerve fiber layer; pRNFL = peripapillary retinal nerve fiber layer; VEP = visual evoked potential.

Values are Pearson r. Thickness changes are relative to the affected eye at baseline except for the pRNLF thickness change, which is relative to the unaffected eye at baseline.

^aCompared with the unaffected eye at baseline.