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. 2024 Apr 12;16(2):e12581. doi: 10.1002/dad2.12581

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© 2024 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

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Impact of mild cognitive impairment (MCI) on the association between cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarker levels and estimated glomerular filtration rate (eGFR). Interaction analysis performed using linear mixed models to assess differences in the relationship between CSFAD biomarker levels: (A) amyloid beta (Aβ)42, (B) tau, (C) phosphorylated tau (p‐tau), and (D) Aβ42/tau ratio and eGFR based on cognitive status. The slope and intercept are plotted separately for individuals with MCI and those with normal cognition (NC). The p‐value presented is for the interaction term (eGFR*MCI); it suggests a significant difference in the association between these variables based on cognitive status.