TABLE 1.
Descriptive characteristics of the pooled sample.
| Characteristic | Combined sample | NC | MCI | p‐value a |
|---|---|---|---|---|
| N | 973 | 560 (57.6%) | 413 (42.4%) | |
| Age, years, mean (SD) | 66.52 (8.83) | 64.7 ± 8.3 | 69.0 ± 8.9 | <0.001 |
| Sex (%) | ||||
| Female | 613 (63%) | 383 (68.4%) | 230 (55.7%) | <0.001 |
| Male | 360 (37%) | 177 (31.6%) | 183 (44.3%) | |
| Race (%) | ||||
| AA | 227 (23.33) | 114 (20.4%) | 113 (27.4%) | 0.011 |
| White | 746 (76.67%) | 446 (79.6%) | 300 (72.6%) | |
| eGFR, mean (SD) | 78.00 (16.70) | 79.2 (15.9) | 76.3 (17.6) | 0.007 |
| Aβ42, pg/mL, mean (SD) | 385.15 (178.22) | 457.2 (184.1) | 287.5 (111) | <0.001 |
| tau, pg/mL, mean (SD) | 66.75 (43.29) | 51.3 (23.4) | 87.6 (53.9) | <0.001 |
| p‐tau, pg/mL, mean (SD) | 31.52 (22.08) | 24.9 (11.9) | 40.6 (28.6) | <0.001 |
| Aβ42/tau ratio, mean (SD) | 8.06 (6.09) | 10.7 (6.4) | 4.5 (3.1) | <0.001 |
Abbreviations: AA, African American; Aβ42, amyloid beta42; eGFR, estimated glomerular filtration rate; MCI, mild cognitive impairment; N, sample size; NC, normal cognition; p‐tau, phosphorylated tau; SD, standard deviation; tau, tau protein.
a
p‐values obtained through a pooled analysis using t‐test for continuous data and chi‐square for discrete data.