TABLE 2.

Association of CSF biomarkers with estimated glomerular filtration rate from the pooled sample. ^a

Biomarker	Slope b per unit of eGFR (95% CI)	p‐value	MCI adjusted slope c per unit of eGFR (95% CI)	p‐value
Aβ42, pg/mL	0.75, (0.27, 1.23)	0.002	0.52 (0.03, 1.01)	0.04
tau, pg/mL	−0.39, (−0.55, −0.23)	<0.001	−0.23 (−0.38, −0.09)	0.001
p‐tau, pg/mL	−0.13, (−0.19, −0.06)	0.0002	−0.07 (−0.14, −0.01)	0.02
Aβ42/tau ratio	0.033, (0.02, 0.05)	<0.001	0.03 (0.01, 0.04)	0.002

Abbreviations: Aβ42, amyloid beta42; 95% CI%, 95% confidence Interval; eGFR, estimated glomerular filtration rate; MCI, mild cognitive impairment; ‐p‐tau, phosphorylated tau; tau, tau protein.

^a p‐values were obtained from the meta‐analysis using linear mixed‐effects models and “study” as a random effect.

^b Change is the beta coefficient for the change in the CSF biomarker levels per change in eGFR.

^c Change is the beta coefficient for the change in the CSF biomarker levels per change in eGFR adjusted for MCI.