TABLE 3.

Interaction between MCI, CSF biomarkers, and eGFR from the pooled sample. ^a

Biomarkers	Effects	β	95% CI	p‐value b
Aβ42, pg/mL	eGFR*MCI	1.37	(0.4, 2.33)	0.005
tau, pg/mL	eGFR*MCI	−0.30	(−0.59, −0.01)	0.04
p‐tau, pg/mL	eGFR*MCI	−0.13	(−0.25, 0)	0.05
Aβ42/tau ratio	eGFR*MCI	0.03	(0, 0.06)	0.05

Abbreviations: β, beta coefficient for interaction between CSF biomarkers; 95% CI, 95% confidence Interval; eGFR, estimated glomerular filtration rate; MCI, mild cognitive impairment; p‐tau, phosphorylated tau; tau, tau protein; Aβ42, amyloid beta 42.

^a Model includes the interaction term eGFR*MCI and uses “study” as a random effect.

^b p‐values obtained through meta‐analysis of the data from both studies (B‐SHARP and CRIN).