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Challenge of vaccinated macaques with MuSIV+. (A) Map of the SIV-MLV hybrid MuSIV+. MLV-derived sequences are marked by black boxes; inactivated reading frames are shaded. (B) Cell-associated viral load in macaques challenged with MuSIV+. Infectious cells/106 PBMCs were calculated from the minimal number of PBMCs required for virus isolation in cocultures with Raji cells. LTR, long terminal repeat; SU, surface protein; TM, transmembrane protein.
