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. 2024 Apr 12;8(6):bvae049. doi: 10.1210/jendso/bvae049

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.

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Figure 3. — A 72-year-old man (patient 9) with a metastatic neuroendocrine tumor underwent radical left nephrectomy and had resection of a left pararenal mass. Postoperatively he had high normetanephrines, and urinary norepinephrine and dopamine levels. Positron emission tomography (PET) imaging was performed following intravenous injection of 306 MBq (8.3 mCi) of 3-[¹⁸F]fluoro-para-hydroxyphenethylguanidine (3-[¹⁸F]pHPG). Left: 3-[¹⁸F]pHPG MIP image at 90 minutes demonstrates multifocal metastases in the liver (standardized uptake value [SUV_max] of 103), abdominal and thoracic lymph nodes, lungs, and bones (SUV_max of 73). 3-[¹⁸F]pHPG activity is also seen in the parotid glands, thyroid, heart, liver, and pancreas, and there is genitourinary excretion of radiotracer in the kidneys and bladder. Right: Axial fused PET/CT slices showing intense 3-[¹⁸F]pHPG activity in malignant disease in the lungs (arrowheads, top), liver (long arrows, middle), and retroperitoneal abdominal nodes (short arrow, bottom). There is uptake in lytic/sclerotic bone metastases in the thoracic spine (bottom).