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. 2024 Apr 12;8(6):bvae049. doi: 10.1210/jendso/bvae049

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.

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Figure 4. — A 43-year-old woman (patient 2) with metastatic paraganglioma. Comparison between left: [⁶⁸Ga]DOTATATE PET, middle: 3-[¹⁸F]pHPG PET, and right: [¹²³I]mIBG scan. She initially presented with preeclampsia and was found to have a large abdominal paraganglioma. Clinically she had worsening hypertension, palpitations, lightheadedness, and shortness of breath. Computed tomography scan revealed a mass posterior to the pancreas, between the aorta and vena cava, and there was metastatic osseous disease in the right orbital ridge and in the thoracic and lumbar spine (standardized uptake value [SUV_max] of 38.7). She underwent exploratory celiotomy and excision of retropancreatic paraganglioma (arrow), seen on the preoperative [⁶⁸Ga]DOTATATE PET, which has been surgically resectioned on the postoperative 3-[¹⁸F]pHPG PET. 3-[¹⁸F]pHPG PET and [⁶⁸Ga]DOTATATE PET had similar detection of osseous metastases, though 3-[¹⁸F]pHPG PET detected a liver metastases (SUV_max of 4.1) not evident on [⁶⁸Ga]DOTATATE PET, likely due to lower background hepatic activity. 3-[¹⁸F]pHPG PET detected more bone metastases than the comparison postoperative [¹²³I]mIBG scan.