Table 1.
Target | Intervention | Conditions | Phase | Status | Number Enrolled | NCT |
---|---|---|---|---|---|---|
Adenosine A2B Receptor antagonist; Chemotherapy |
PBF-1129 and Nivolumab | NSCLC | I | Recruiting | 30 | NCT05234307 |
Chemotherapy; Electrothermal therapy |
Gemcitabine; Focused Ultrasound; Gemcitabine and Focused Ultrasound |
Breast Cancer | I | Recruiting | 48 | NCT04796220 |
Chemotherapy | Tadalafil | Astrocytoma | I | Completed | 18 | NCT04757662 |
Endocrine Therapy; Chemotherapy | Abemaciclib; Fulvestrant; Aromatase Inhibitors | Breast Cancer | II | Active, not recruiting | 18 | NCT04352777 |
Anti-PD-1; Chemotherapy |
Nivolumab; Nivolumab and Gemcitabine | NSCLC | II | Terminated | 3 | NCT03302247 |
Chemotherapy | Fludarabine; Busulfan; Methotrexate | Leukemia | I | Active, not recruiting | 20 | NCT02916979 |
CXCR1/2 antagonist; Anti-PD-1 |
SX-682 and Pembrolizumab | Melanoma | I | Recruiting | 77 | NCT03161431 |
PDE-5 inhibitor | Tadalafil |
Head and Neck Squamous Cell Carcinoma |
II | Completed | 40 | NCT01697800 |
Anti-PD-1; ATRA |
Pembrolizumab with ATRA | Melanoma | I/II | Active, not recruiting | 26 | NCT03200847 |
Anti-PD-1; ATRA |
ATRA and Atezolizumab | NSCLC | I | Recruiting | 18 | NCT04919369 |
ATRA; Anti-CTLA-4 |
ATRA; Ipilimumab | Melanoma | II | Active, not recruiting | 10 | NCT02403778 |
H2 receptor antagonist | Ranitidine | Cancer | IV | Completed | 30 | NCT03145012 |
TLR9 agonist; Anti-PD-1 |
CMP-001 and Nivolumab |
Melanoma; Lymph Node Cancer |
II | Active, not recruiting | 34 | NCT03618641 |
Chemotherapy; Anti-VEGF |
Capecitabine; Bevacizumab |
Recurrent Glioblastoma | I | Active, not recruiting | 12 | NCT02669173 |
MDSCs, myeloid-derived suppressor cells; MNPs, mononuclear phagocytes; DCs, dendritic cells; ImCs, immature cells; MSCs, myeloid suppressor cells; PMN-MDSCs, polymorphonuclear-MDSCs; M-MDSCs, monocytic MDSCs; ARG1, arginase 1; MMP-9, metalloproteinase-9; PD-L1, programmed death ligand 1; HLA-I, human leukocyte antigens class I; CMPs, common myeloid progenitors; GMPs, granulocyte–macrophage progenitors; MB, myeloblasts; MDP, monocyte/macrophages and dendritic cell; IL-17A, Interleukin-17A; GM-CSF, granulocyte–macrophage colony-stimulating factor; G-CSF, granulocyte colony-stimulating factor; TNF-α, tumor necrosis factor-alpha; CCR2, C–C chemokine receptor 2; CCR5, C–C chemokine receptor 5; TGF-β, transforming growth factor beta; CD62L, L-selectin2; ADAM17, a disintegrin and metalloproteinase domain 17; TACE, TNF-α-converting enzyme; HMGB1, high mobility group box-1; ROS, reactive oxygen species; VEGF, vascular endothelial growth factor; TCR, T-cell receptor; MHC, major histocompatibility complex; RNS, reactive nitrogen species; NO, nitric oxide; Trp, tryptophan; TME, tumor microenvironment; CAT-2B, cationic amino acid transporter protein; IDO1, indoleamine-2,3-dioxygenase 1; AhR, aryl hydrocarbon receptor; PD-1, programmed cell death 1; VISTA, V-domain Ig suppressor of T-cell activation; Gal-9, galactose lectin-9; AML, acute myeloid leukemia; TIM-3, T-cell immunoglobulin and mucin structural domain 3; STING, stimulator of interferon genes; TIGIT, T-cell immunoglobulin and ITIM domain; HNSCC, head and neck squamous cell carcinoma; NK, Natural killer; NKG2D, natural killer group 2D; IFN-γ, interferon-γ; STAT3, signal transducer and activator of transcription 3; NF-Κb, nuclear factor-κB; IL-10, interleukin-10; IL-12, interleukin-12; Treg, regulatory T; LTB4, leukotriene B4; EV, extracellular vesicles; HSP90α, heat shock protein 90α; NLRP3, NOD-like receptor protein 3; CCN4, Cell Communication Network Factor 4; HCC, Hepatocellular carcinoma; CAFs, cancer-associated fibroblasts; MIF, migration inhibitory factor; SLC7A11, solute carrier family 7 member 11; CSF1, colony-stimulating factor 1; SLC7A2, Solute carrier family 7 member 2; PI3K, phosphatidylinositol 3-kinase; AKT, protein kinase B; RIP3, receptor-interacting protein kinase 3; ENTPD2, ectonucleoside triphosphate diphosphohydrolase 2; HIF-1, hypoxia-inducible factor-1; ATP, adenosine triphosphate; 5'-AMP, 5'-Adenosine monophosphate; PIWIL1, Piwi Like RNA-Mediated Gene Silencing 1; FAO, fatty acid β-oxidation; AR, androgen; CCRK, cell cycle-related kinase; EZH2, Enhancer of zeste homolog 2; BC, breast cancer; GMPs, granulocyte-monocyte progenitors; GPs, granulocyte progenitors; BM, bone marrow; CCL20, C–C motif chemokine ligand 20; BCSC, breast cancer stem cells; NO, nitric oxide; CEBPB, CCAAT/enhancer-binding protein beta; AMPK, AMP-activated protein kinase; MAPK, mitogen-activated protein kinase; AMPKα, AMP-activated protein kinase alpha; eMDSCs, early myeloid-derived suppressor cells; JAK, Janus kinase; SOCS3, suppressor of cytokine signaling-3; PIAS3, protein inhibitor of activated STAT-3; SMAD3, Smad family member 3; KAT6A, lysine acetyltransferase 6A; TRIM, tripartite motif‐containing; Enpp1, ectonucleotide pyrophosphatase/phosphodiesterase 1; NET, neutrophil extracellular traps; PCa, Prostate cancer; ICB, immune checkpoint blockade; CRPC, castration resistant prostate cancer; IL-23, Interleukin-23; CHD1, chromodomain-helicase-DNA-binding protein 1; PTEN, Phosphatase and tensin homolog; LC, Lung cancer; NSCLC, non-small cell lung cancer; IL-7, Interleukin-7; Gprc5a, G-protein–coupled receptor, family C, member 5A; PTGES, PGE synthase; PGE2, prostaglandin E2; GALNT3, polypeptide N-acetyl-galactosaminyltransferase 3; PDH, pyruvate dehydrogenase; CAFs, Cancer-associated fibroblasts; PDAC, pancreatic ductal adenocarcinoma; AML, acute myeloid leukemia; CAC, colitis-associated cancer; FGFR1, fibroblast growth factor receptor-1; TRAIL, TNF-related apoptosis-induced ligand; SHP2, phosphatase 2; Aza, azacytidine; PDE-5, Phosphodiesterase-5; CIK, cytokine-induced killer; Gal-3, alactose lectin-3; Hv1, voltage-gated proton channels; COX-2, cyclo-oxygenase 2; BTK, Bruton’s tyrosine kinase; UPR, unfolded protein response;ATRA, All-trans retinoic acid