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. 2024 Apr 10;221(6):e20231236. doi: 10.1084/jem.20231236

Figure 1.

Figure 1.

TL1A is an epithelial cytokine expressed in alveolar epithelium and airway basal cells in human healthy and asthmatic lungs. (A) Single-cell RNA-seq analysis of TNFSF15 (TL1A) expression in the LungMAP single-cell human lung atlas. Uniform manifold projection (UMAP) plots show the clustering of 347,970 lung cells (10 single-cell datasets, 148 normal human lung samples from 104 donors: adult, child, and adolescent). Results are visualized using ShinyCell (Ouyang et al., 2021) and are based upon data generated by the LungMAP Consortium (Guo et al., 2023) and downloaded from http://www.lungmap.net (Gaddis et al., 2024). (B and C) Single-cell RNA-seq analysis of TNFSF15 (TL1A) expression in epithelial cells from human healthy (B) and asthmatic (C) lungs. t-SNE plots show clustering of 26,154 epithelial cells in upper and lower airways and lung parenchyma in healthy lungs (B; 17 human samples: 6 alveoli and parenchyma, 9 bronchi, 2 nasal), and 25,146 epithelial cells from lower airways in healthy and asthmatic lungs (C; 12 human samples: 15,033 cells from 6 asthma bronchi; 10,113 cells from 6 control bronchi). t-SNE plots were extracted from data obtained by the human lung single-cell atlas (Vieira Braga et al., 2019) and downloaded from https://asthma.cellgeni.sanger.ac.uk.