Table 1.

Necroptotic factors and their roles in necroptosis.

Necroptotic factors	Key roles in necroptosis	Antagonists
RIPK1	Being deubiquitinated under apoptosis-deficient conditions, interacts with RIPK3 to form necrosome	Necrostatin-1 (Nec-1)	[6]
RIPK3	Forms necrosome with RIPK1 and phosphorylates MLKL	GSK843, GSK872	[36]
MLKL	Being phosphorylated by RIPK3, oligomerizes and translocates to plasma membrane to induce membrane permeabilization and necroptosis	Necrosulfonamide (NSA)	[37]
cIAP1/2	Polyubiquitinates RIPK1 via K63-linkage to induce NF-κB signaling	SMAC mimetics	[38]
LUBAC	Polyubiquitinates RIPK1via M1-linkage to induce NF-κB signaling
CYLD	Deubiquitinates RIPK1 to promote complex II formation
A20	Deubiquitinates RIPK1 to promote complex II formation