Table 2.
Downregulations and mutations of necroptotic factors in cancer.
| Cancer | Necroptotic factors downregulated in cancer | |
|---|---|---|
| Acute myeloid leukemia | RIPK3 | [64] |
| Chronic lymphocytic leukemia | CYLD | [53] |
| Melanoma | RIPK3, CYLD | [54] [65] |
| Breast cancer | RIPK3 | [66] |
| Colorectal cancer | RIPK3, MLKL, CYLD | [55] [56] [67] |
| Head and neck squamous cell carcinoma | RIPK1 | [68] |
| Gastric cancer | MLKL | [69] |
| Ovarian cancer | MLKL | [70] |
| Mutation | Expected effect on function | |
| RIPK3 V458M | Identified in RHIM domain: Loss-of-function | [60] |
| MLKL L291P | Identified in pseudokinase domain: Loss-of-function | [63] |