FIG. 6.

A higher TNR for 6QC-ICG than for 5-ALA was found in tissue homogenates from mouse GBM models. A: A schematic workflow of the spectrofluorimetric analysis of tumor and nontumorous brain tissue in mice coadministered with 6QC-ICG and 5-ALA (ex/em 795/823 nm for 6QC-ICG, ex/em 402/635 nm for 5-ALA). B–D: TNR of 6QC-ICG or 5-ALA in Gl261 (n = 10 mice from two independent experiments) (B), U251 (n = 9 mice from two independent experiments) (C), and NCH644 (n = 5 mice from one experiment) (D) GBM models. *p < 0.05, **p < 0.01, Wilcoxon signed-rank test. Panel A was created using BioRender.com.