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. 2024 Mar 26;16(7):1285. doi: 10.3390/cancers16071285

Table 3.

Toxicity during induction and supportive agents.

Global Group
(N = 405) 		R-CHOP
(N = 245) 		R-BENDA
(N = 160) 		p
Pneumocystis carinii prophylaxis (induction): 184 (48%) 125 (55%) 59 (39%) 0.003
Herpes prophylaxis (induction): 124 (32%) 64 (28%) 60 (39%) 0.02
G-CSF during induction:
  • -

    No

  • -

    Primary prophylaxis

  • -

    Secondary prophylaxis
158 (42%)
114 (30%)
107 (28%)
69 (30%)
97 (42%)
65 (28%)
89 (60%)
17 (11%)
42 (28%)		 <0.001
Median number of cycles (range) 6 (2–8) 6 (3–8) 6 (2–8) <0.001
1st line discontinuation: 13 (3%) 4 (2%) 9 (6%) 0.04
Neutropenia:
  • -

    No

  • -

    Grade 1–2

  • -

    Grade 3–4
167 (43%)
66 (17%)
157 (40%)
82 (35%)
51 (22%)
102 (43%)
85 (55%)
15 (10%)
55 (35%)		 <0.001
Anemia:
  • -

    No

  • -

    Grade 1–2

  • -

    Grade 3–4
255 (65%)
126 (32%)
14 (3%)
125 (52%)
104 (43%)
12 (5%)
130 (84%)
22 (14%)
2 (1%)		 <0.001
Thrombocytopenia:
  • -

    No

  • -

    Grade 1–2

  • -

    Grade 3–4
327 (82%)
68 (16%)
2 (1%)
196 (81%)
45 (19%)
1 (0.4%)
131 (84%)
23 (15%)
1 (1%)		 0.46
Liver toxicity:
  • -

    No

  • -

    Grade 1–2

  • -

    Grade 3–4
377 (95%)
13 (3%)
1 (1%)
226 (94%)
11 (5%)
4 (2%)
151 (98%)
2 (1%)
1 (1%)		 0.14
Renal toxicity:
  • -

    No

  • -

    Grade 1–2

  • -

    Grade 3–4
388 (98%)
5 (1%)
3 (1%)
238 (99%)
2 (1%)
1 (0.5%)
150 (97%)
3 (2%)
2 (1%)		 0.39
Infections: 93 (24%) 61 (25%) 32 (21%) 0.33
  Infections during induction:
  •     -

    No

  •     -

    Grade 1–2

  •     -

    Grade 3–4

 94 (24%)
299 (76%)
55 (14%)
39 (10%)		 61 (25%)
179 (75%)
35 (15%)
26 (11%)		 33 (22%)
120 (78%)
20 (13%)
13 (8%)
0.4
0.65
  Infections during maintenance:
  •     -

    No

  •     -

    Grade 1–2

  •     -

    Grade 3–4

 64 (19%)
277 (81%)
49 (14%)
15 (4%)		 27 (13%)
177 (87%)
20 (10%)
7 (3%))		 37 (27%)
100 (73%)
29 (21%)
8 (6%)
<0.001
0.006
Dermatologic toxicity: 35 (9%) 20 (9%) 15 (10%) 0.72
Hospitalization: 70 (18%) 48 (20%) 22 (14%) 0.18