Figure 1.

Representative photomicrographs of prostates from four prostate-specific genetic groups: (1) R26^MTA1; Pb-Cre-negative (WT), (2) R26^MTA1, (3) Pten^f/f, and (4) R26^MTA1; Pten^f/f were evaluated using H&E staining (scale bar, 100 µm). The prostate in WT mice is unremarkable (upper left). In R26^MTA1 mice, there is an occasional hyperplasia of the prostatic epithelium without nuclear or cellular atypia (upper right). In Pten^f/f and R26^MTA1; Pten^f/f mice, both PIN and prostatic adenocarcinoma are observed. The images (lower left and right) show well to moderately differentiated invasive prostatic adenocarcinoma with desmoplasia and inflammatory infiltrates.