AKT	v-akt murine thymoma viral oncogene (protein kinase B)
ANOVA	Analysis of variance
AR	Androgen receptor
bw	Body weight
CC3	Cleaved caspase 3
CD31	Cluster of differentiation 31
CRPC	Castration-resistant prostate cancer
DEGs	Differentially expressed genes
DMSO	Dimethyl sulfoxide
Ctrl	Control
ELISA	Enzyme-linked immunosorbent assay
ERK1/2	Extracellular signal-regulated kinase 1/2
FDR	False discovery rate
GAPDH	Glyceraldehyde 3-phosphate dehydrogenase
f/f	Pten gene flanked by two loxP sites in each allele
GnC	gnetin C
GRCm39	Genome reference consortium mouse build 39
H&E	Hematoxylin and eosin
HED	Human equivalent dose
HSP70	Heat shock protein 70
IACUC	Institutional Animal Care and Use Committee
IHC	Immunohistochemistry
IL-2	Interleukin 2
i.p.	Intraperitoneal
Ki67	Cellular protein marker of proliferation
LIU	Long Island University
mTOR	mammalian target of rapamycin
ns	Non-significant
NS	Non-silenced
OE	Overexpression
p-AKTS473	Phosphorylation of serine 473 in C-terminus of AKT
p-4EBP1	Phosphorylated eukaryotic translational initiation factor 4E (elF4E)-binding protein 1
p-S6K	Phosphorylated p70 ribosomal protein S6 kinase
p-mTOR	Phosphorylated mammalian target of rapamycin
Pb-Cre+	Probasin promoter directing expression of epithelial Cre recombinase
PC3M	Human prostate cancer cell line
PCR	Polymerase chain reaction
PI3K	Phosphoinositide 3-kinase
PIN	Prostate intraepithelial neoplasia
PTEN	Phosphatase and tensin homolog
Pten+/f	Pten heterozygous mice
Ptenf/f	Pten homozygous, Pten-null
qRT-PCR	Quantitative reverse transcriptase polymerase chain reaction
RNA	Ribonucleic acid
RPMI-1640	Roswell Park Memorial Institute 1640 cell culture media
R26	Rosa26 loci in the mouse genome
SEM	Standard error of mean
shMTA1	short hairpin MTA1
shNS	short hairpin non-silence
UGS	Urogenital system
WT	Wild-type