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Neuroblastoma patients bearing a tumor with MYCN amplification or high MYCN mRNA levels show a poor prognosis. (A) Oncoprint of somatic mutations shows the genetic alterations and mRNA expression levels of MYCN, EGFR, EGF, MAPK1 and CTSD in pediatric NB patients (TARGET, 2018). (B) Scatter plots representing the correlations between MYCN–CTSD (a), MYCN–EGFR (b), MYCN–MAPK1 (c) and CTSD–MAPK1 (d) mRNA expression.
