Table 1.

Bioanalytical characterization of ADCs.

ADC	DAR	ppm P *	ppm S °	mol P/mol S	nM N-BPs/mL 2 µg/mL ADC **
Cet-IBA	5.7	65 ± 2	40 ± 4	1.7	74.1
Cet-RIS	7.1	74 ± 2	35 ± 1	2.2	92.3
Cet-ZA	3.6	16 ± 2	38 ± 1	0.4	46.8

DAR: drug–antibody ratio; ° part per million of either phosphorus (*) or sulfur (°). ** Concentration of the N-BPs linked to Cet in the solution used to assess antibody reactivity and functional effects.