Table 1.
Prevalence of low-volume metastases in apparent early-stage EC.
| First Author | Study Period | Country | Number of Patients | Patients with LVM (%) | Patients with MM (%) | Patients with ITCs (%) |
|---|---|---|---|---|---|---|
| Studies reporting data on prevalence of LVM, MM, and ITCs | ||||||
| Ballester [31] | 2007–2009 | France | 111 | 7 (6.3) | 6 (5.4) | 1 (0.9) |
| Holloway [37] | 2006–2013 | USA | 119 | 22 (18.5) | 10 (8.4) | 12 (10.1) |
| Clinton [62] | 2012–2015 | USA | 185 | 12 (6.5) | 3 (1.6) | 9 (4.9) |
| Euscher [51] | 2007–2014 | USA | 178 | 22 (12.4) | 14 (7.9) | 8 (4.5) |
| Plante [63] | 2010–2015 | Canada | 519 | 42 (8) | 11 (2) | 31 (6) |
| Rossi [25] | 2012–2015 | USA | 293 | 19 (6.5) | 9 (3.1) | 10 (3.4) |
| Backes [64] | 2013–2016 | USA | 184 | 11 (6) | 2 (1.1) | 9 (4.9) |
| Kennard [65] | 2011–2016 | USA | 414 | 57 (13.7) | 21 (5) | 36 (8.7) |
| Martinelli [66] | 2005–2019 | Italy | 221 | 14 (6.3) | 6 (2.7) | 8 (3.6) |
| Garcia Pineda [67] | 2007–2016 | Spain | 230 | 14 (6.1) | 8 (3.5) | 6 (2.6) |
| Mueller [60] | 2005–2018 | USA | 1044 | 106 (10.2) | 45 (4.4) | 61 (5.8) |
| Lavecchia [59] | 2015–2019 | Canada, Korea | 1012 | 19 (1.9) | 7 (0.7) | 12 (1.2) |
| Buda [68] | 2012–2020 | Europe | 1428 | 76 (5.3) | 50 (3.5) | 26 (1.8) |
| Total | 5938 | 421 (7.1) | 192 (3.2) | 229 (3.9) | ||
| Studies reporting data on prevalence of LVM only | ||||||
| Desai [69] | 2011–2013 | USA | 103 | 5 (4.9) | NR | NR |
| Studies reporting data on prevalence of ITCs only | ||||||
| Goebel [70] | 2012–2016 | USA | 155 | NR | NR | 21 (13.5) |
| Matsuo [71] | 2018 | USA | 6472 | NR | NR | 111 (1.7) |
| Mumford [72] | 2017–2020 | USA | 848 | NR | NR | 33 (3.9) |
Abbreviations: EC: endometrial carcinoma; LVM: low-volume metastases; MM: micrometastases; ITCs: isolated tumor cells; NR: not reported.