Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
(A) Chemical structure of CF10; (B) scheme depicting the conversion of CF10 to 10× equivalents of fluorodeoxyuridylate, while only ~5% (0.05×) of 5-FU is converted to FdUMP. TS inhibition results in the depletion of TTP that causes replication fork stalling and collapse. The misincorporation of FdUTP into DNA causes the formation of DNA topoisomerase 1 cleavage complexes (Top1ccs) that stall replication forks.
