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CF10 activates the ATR/Chk1 pathway, consistent with replication stress, and causes DNA DSBs in CC531 cells. Western blots from CC531 cell lysates: (A) CF10 dose–response graphs demonstrate that a 250 nM dose is sufficient for ATR/Chk1 pathway activation and DNA DSBs; (B) equimolar 5-FU is not effective in ATR/Chk1 activation and DNA DSBs; and (C) a 10-fold greater 5-FU dose is relatively less effective than 250 nM CF10. * indicates mono-ubiquitnated FANCD2.
