Table 2.
Univariate and multivariate analysis of potential risk factors impacting overall survival.
| Characteristics | Variable (Percentage) | HR (Univariate) | HR (Multivariate) |
|---|---|---|---|
| Median age at transplant | 48.8 years (18.3–71.0) | 1.01 (1.00–1.02, p = 0.26) | - |
| Gender | |||
| Male | 194 (51.6%) | - | - |
| Female | 182 (48.4%) | 0.68 (0.51–0.90, p = 0.008) | 0.89 (0.65–1.23, p = 0.48) |
| ELN 2017 subgroup | |||
| Favorable | 41 (10.9%) | - | - |
| Intermediate | 159 (42.3%) | 1.26 (0.73–2.16, p = 0.40) | 1.14 (0.66–1.95, p = 0.65) |
| Adverse | 105 (27.9%) | 2.06 (1.20–3.55, p = 0.009) | 1.50 (0.85–2.64, p = 0.16) |
| Status at transplant | |||
| CR | 304 (80.9%) | - | - |
| Refractory | 72 (19.1%) | 3.67 (2.71–4.99, p < 0.001) | 3.75 (1.95–7.22, p < 0.001) |
| Conditioning | |||
| RIC | 209 (55.6%) | - | - |
| MAC | 120 (31.9%) | 1.00 (0.72–1.38, p = 0.99) | 0.82 (0.53–1.26, p = 0.36) |
| Sequential | 47 (12.5%) | 2.80 (1.93–4.06, p < 0.001 | 0.73 (0.37–1.46, p = 0.37) |
| Type of graft | |||
| PBSC | 244 (64.9%) | - | - |
| BM | 96 (25.5%) | 0.87 (0.62–1.22, p = 0.43) | - |
| CB | 36 (9.6%) | 1.06 (0.67–1.68, p = 0.81) | - |
| Type de donor | |||
| MSD | 177 (47.1%) | - | - |
| MUD | 124 (33%) | 1.15 (0.84–1.58, p = 0.39) | - |
| Haplo | 16 (4.3%) | 1.49 (0.75–2.97, p = 0.25) | - |
| 9/10 | 23 (6.1%) | 1.26 (0.71–2.27, p = 0.43) | - |
| CB | 36 (9.6%) | 1.20 (0.74–1.93, p = 0.46) | - |