Table 3.
Univariate and multivariate analyses of potential risk factors impacting relapse-free survival.
| Characteristics | Variable (Percentage) | HR (Univariate) | HR (Multivariate) |
|---|---|---|---|
| Median age at transplant | 48.8 years (18.3–71.0) | 1.01 (1.00–1.02, p = 0.22) | - |
| Gender | |||
| Male | 194 (51.6%) | - | - |
| Female | 182 (48.4%) | 0.70 (0.53–0.92, p = 0.01) | 0.90 (0.66–1.23, p = 0.52) |
| ELN 2017 subgroup | |||
| Favorable | 41 (10.9%) | - | - |
| Intermediate | 159 (42.3%) | 1.29 (0.75–2.20, p = 0.35)) | 1.17 (0.68–2.00, p = 0.58)) |
| Adverse | 105 (27.9%) | 2.24 (1.30–3.85, p = 0.004) | 1.66 (0.95–2.91, p = 0.08) |
| Status at transplant | |||
| CR | 304 (80.9%) | - | - |
| Refractory | 72 (19.1%) | 3.66 (2.70–4.94, p < 0.001) | 3.06 (1.59–5.89, p = 0.001) |
| Conditioning | |||
| RIC | 209 (55.6%) | - | - |
| MAC | 120 (31.9%) | 0.90 (0.65–1.23, p = 0.51) | 0.83 (0.54–1.26, p = 0.37) |
| Sequential | 47 (12.5%) | 2.95 (2.04–4.26, p < 0.001) | 0.90 (0.45–1.80, p = 0.76) |
| Type of graft | |||
| PBSC | 244 (64.9%) | - | - |
| BM | 96 (25.5%) | 0.80 (0.58–1.11, p = 0.19) | - |
| CB | 36 (9.6%) | 1.11 (0.71–1.74, p = 0.65) | - |
| Type de donor | |||
| MSD | 177 (47.1%) | - | - |
| MUD | 124 (33%) | 1.17 (0.86–1.60, p = 0.32) | - |
| Haplo | 16 (4.3%) | 1.34 (0.68–2.67, p = 0.40) | - |
| 9/10 | 23 (6.1%) | 1.43 (0.83–2.47, p = 0.20) | - |
| CB | 36 (9.6%) | 1.30 (0.82–2.08, p = 0.26) | - |