Table 2.
LAMP-2-ANCA seropositivity in pediatric chronic primary systemic vasculitis (PSV).
| PSV Total (n = 90) |
Small Vessel (n = 53) |
Medium Vessel (n = 16) |
Large Vessel (n = 21) |
|||||
|---|---|---|---|---|---|---|---|---|
| a LAMP-2-ANCA | − | + | − | + | − | + | − | + |
| n | n = 41 | n = 49 | n = 29 | n = 24 | n = 7 | n = 9 | n = 5 | n = 16 |
| % | 45.6% | 54.4% | 54.7% | 45.3% | 41.2% | 52.9% | 23.8% | * 76.2% |
| b Sex, n (%) | ||||||||
| Female | 26 (63.4) | 34 (69.4) | 18 (62.1) | 17 (70.8) | 4 (57.1) | 6 (66.7) | 4 (80.0) | 11 (68.8) |
| Male | 15 (36.6) | 15 (30.6) | 11 (37.9) | 7 (29.2) | 3 (42.9) | 3 (33.3) | 1 (20.0) | 5 (31.2) |
| c Age of onset, years | ||||||||
| Median | 13.8 | 13.2 | 14.5 | 13.1 | 8.1 | 13.7 | 10.5 | 13.2 |
| Range | 1.9–17.3 | 1.9–17.2 | 1.9–17.8 | 1.9–17.2 | 2.7–15.5 | 4.0–15.8 | 3.7–13.3 | 5.3–17.1 |
| d ANCA antigen positivity, n (%) | ||||||||
| PR3 | 19 (22.4) | 11 (12.9) | 18 (34.6) | 11 (21.2) | 1 (5.9) | − | − | − |
| MPO | 9 (10.6) | 9 (10.6) | 9 (17.3) | 9 (17.3) | − | − | − | − |
| PR3 and MPO | 1 (1.2) | 1 (1.2) | 1 (1.9) | 1 (1.9) | − | − | − | − |
| Neither | 12 (14.1) | 23 (27.1) | 1 (1.9) | 2 (3.8) | 6 (35.3) | 8 (47.1) | 5 (27.8) | 13 (72.2) |
a LAMP-2-ANCA-seronegative indicated by (−) and -seropositive indicated by (+). b Percentage calculated from the total seronegative or seropositive participants of the same vessel size; no statistically significant differences (chi-squared test) between seropositive and seronegative individuals in the PSV (0.5494), SVV (0.5024), MVV (0.6963), and LVV (0.6269) groups. c No statistically significant differences between seropositive and seronegative individuals in the PSV (0.7235, Mann–Whitney test), SVV (0.1479, Mann–Whitney test), MVV (0.1146, unpaired t-test), and LVV (0.1085, unpaired t-test) groups. d Percentage calculated based on available data for participants within the PSV (85/90), SVV (52/53), MVV (15/16), and LVV (18/21) groups. * Significant difference in the prevalence of seropositive individuals between SVV and LVV (p = 0.0162) based on chi-squared test. Across all groups, p = 0.0545 for the prevalence of seropositivity; SVV vs. MVV, p = 0.4415; MVV vs. LVV, p = 0.1993.