Table 3.
Case reports and case series reported so far in the literature are summarized. TS: corticosteroids; CI: calcineurin inhibitors; ASA: acid acetylsalicilic; UVB: ultraviolet B; PDL: pulsed-dye-laser; CR: complete response; PR: partial response; NR: no response.
| Author | Age, Sex | Ulceration | Diabetes | Previous Therapies | PDT | N° Sessions, Interval | Outcome |
|---|---|---|---|---|---|---|---|
| Lopez Sanz et al. [78] | 18, F | No | Yes | TS, CI, oral cyclosporine, PUVA phototherapy | Daylight ALA-PDT | 2, bi-monthly | CR |
| Bernia et al. [67] | 21, F | No | Yes | Penthoxyfilline, TS, CI, ASA, calcitriol, laser PDL | MAL-PDT | 11, two week | CR |
| 32, F | No | Yes | Pentoxifillina, TS | MAL-PDT | 18, two week | CR | |
| 22, F | No | Yes | TS, CI, PDL | MAL-PDT + ALA | 10, two week | CR | |
| 61, F | No | Yes | TS, cryotherapy | MAL-PDT + ALA | 6, two week | CR | |
| Borgia et al. [6] | 44, F | No | Yes | Not reported. | 10% ALA-PDT | 6, monthly | PR |
| Borgia et al. [68] | 44, F | Yes | Yes | TS, CI, UVB phototherapy | 10% ALA-PDT | 6, two week | CR |
| Kosaka et al. [79] | 66, F | No | Yes | Not reported | 20% ALA-PDT | 9, 2–3 weeks | CR |
| De Giorgi et al. [80] | 31, F | No | Yes | Not reported | 10% ALA-PDT | 4, monthly | CR |
| Heidenheim et al. [81] | 60, F | No | Yes | TS, systemic ascorbic acid and vitamin E, cryotherapy, radiotherapy using grenz rays, systemic allopurinol | MAL-PDT | 3, every week | CR |
| Truchelo et al. [66] | 60, F | No | Yes | TS | MAL-PDT | 2 | NR |
| 35, F | Yes | No | TS | MAL-PDT | 1 | NR | |
| 28, F | No | Yes | TS | MAL-PDT | 3 | PR |