Table 4.

Comparison of deduced amino acid sequences of ORF2 of GII.P31/GII.4_Sydney_2012 variants.

ORF2	NTA			S		P1		P2														P1
	8	9	17	98	119	231	244	285	297	309	310	333	340	372	373	377	378	393	395	407	414	460	534	540
JX459908	A	N	N	G	V	V	I	T	R	N	D	V	T	D	R	A	N	G	T	S	H	Y	T	V
12241/Kyoto/Oct/2013–2014										S	N							S	A		P			L
12283/Kyoto/Feb/2013–2014											N				H			S			P			L
12286/Kyoto/Mar/2013–2014		S							H	S	N				H	T		S			P			L
14146/Kyoto/Dec/2015–2016										S	N	M	A		H			S			P			L
14147/Kyoto/Dec/2015–2016										S	N	M	A		H			S			P			L
14157/Kyoto/Dec/2015–2016		S								S	N				H			S			P			L
14307/Kyoto/Jan/2015–2016							V				N	M	A		H			S			P			L
14311/Kyoto/Feb/2015–2016										S	N	M	A		H		I	S			P			L
17378/Kyoto/Jan/2018–2019	V				I				H	S	N	M		N	N						P		A	L
18792/Kyoto/Sep/2021–2022								A	H	S	N	M		N	N						P		A	L
18794/Kyoto/Sep/2021–2022								A	H	S	N	M		N	N						P		A	L
18821/Kyoto/Oct/2021–2022								A	H	S	N	M		N	N						P		A	L
18958/Shizuoka/Jan/2021–2022	V								H	S	N	M		N	N						P		A	L
18968/Shizuoka/Feb/2021–2022			S	S		I			H	S	N	M		S	N	T				G	P	H	A	L
AB972502/Niigata 2011/JP										S	N							S			P			L
KM272334/KR/2012											N				H
KJ649702/Hu/HKG/2014										S	N	M						S			P			L
KJ451059/2013/TW		S								S	N							S			P			L
LC133344/Osaka/2014/JP										S	N										P			L
LC005734/Hu/JP/2013											N				H			S			P			L
KX354113/2014/USA		S								S	N				H						P			L
OM373200/2018/CHN	V								H	S	N	M		N	N						P		A	L
LC699533/Tokyo/2021								A	H	S	N	M		N	N						P		A	L
OK148516/Hu/GZ19/2018/CHN	V								H	S	N	M		N	N						P		A	L
AB933699/Akita/2011/2006b					I	I					N		G	E	N	T	H				P	H		L
AB933761/Osaka/2011/2009					I						S				N	T		S						L