Table 5.

Comparison of deduced amino acid sequences of ORF3 of GII.P31/GII.4_Sydney_2012 variants.

ORF3	4	13	23	73	78	82	92	101	112	134	137	141	145	146	149	150	159	164	174	181	183	191	211	241	247	268
JX459908	A	V	N	K	M	K	F	I	S	P	S	P	N	L	A	V	S	T	T	T	V	F	S	V	G	A
12241/Kyoto/Oct/2013–2014				R		R	S														G		F	I
12283/Kyoto/Feb/2013–2014				R			S		N												G		F	I
12286/Kyoto/Mar/2013–2014			S	R	V		S		N										A		G	S	F	I	S
14146/Kyoto/Dec/2015–2016				R			S					L									G		F	I	S
14147/Kyoto/Dec/2015–2016				R			S					L									G		F	I
14157/Kyoto/Dec/2015–2016				R			S		N												G		F	I	S
14307/Kyoto/Jan/2015–2016				R			S					L									G		F	I	S
14311/Kyoto/Feb/2015–2016				R			S					L									G		F	I
17378/Kyoto/Jan/2018–2019		I		R			S			S	P			F			F			A	G		F	I		V
18792/Kyoto/Sep/2021–2022	T			R			S	T					-	-				A	I		G		F	I		V
18794/Kyoto/Sep/2021–2022	T			R			S	T					-	-				A	I		G		F	I		V
18821/Kyoto/Oct/2021–2022	T			R			S	T					-	-				A	I		G		F	I		V
18958/Shizuoka/Jan/2021–2022				R			S							F				I	A		G		F	I		V
18968/Shizuoka/Feb/2021–2022				R			S								T	A			I		G		F	I		V
AB972502/Niigata 2011/JP				R			S														G		F	I
KM272334/KR/2012				R			S														G		F
LC726073/Tokyo/2021				R			S							F				I	A		G		F	I		V
MH979230/2018/TW				R			S												I		G		F	I		V
MK928496/TH/2018				R			S							F							G		F	I		V
OM386670/CHN/2019				R			S							F							G		F	I		V
MH702270/Hu/Bhutan/2012				R			S														G		F	I
AB933699/Akita/2011/2006b				R			S							P					V		G		F			V
AB933761/Osaka/2011/2009				R			S														G		F			V