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. 2024 Apr 3;25(7):3995. doi: 10.3390/ijms25073995

Figure 1.

Figure 1

Role of microglia in AD progression. (A) Inactive microglia become activated by stimuli like amyloid β or tau protein deposition. (B) Complete clearance of amyloid β leads to restoration of neurons, and (D) microglia returns to the resting phase. In contrast, (C) failure in amyloid β clearance leads to chronic microglia activation that releases proinflammatory cytokines and neurotoxicity. (E) Entry of the peripheral immune system leads to neurodegeneration. This figure was created using Biorender.com.