Figure 2.

(A) Sections of hippocampus and subiculum immunostained for ionized calcium binding adaptor molecule 1 (Iba1) in 5xFAD mice untreated, treated with 1 mg/kg/day, and treated with 5 mg/kg/day of fingolimod. Untreated 3 month old 5xFAD mice showed significant increase in the number of activated microglial cells. (B) Quantitation of total, active, and resting variants of microglia in the hippocampus of 5xFAD untreated and fingolimod-treated groups. The number of activated Iba1-positive microglia significantly decreased in the hippocampus of 1 mg/kg/day, and 5 mg/kg/day fingolimod-treated groups compared with untreated group (* p < 0.05), (n = 8–10 mice/group) This figure is reprinted under the terms of the Creative Commons Attribution 4.0 International License from reference [99].