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Location of three insertion sites in the SARS-CoV-2 S protein affecting spike–IgV (immunoglobulin variable domain) binding surfaces. The spike protein is shown in magenta (PDB ID: 7cn8), while light (PDB ID: 7cl2) and heavy (PDB ID: 7cl2) chains of 4A8 antibody are in beige and blue, respectively. Sequences of insertions at positions 245, 246, and 248 are shown. The data are taken from [28]. The monosaccharide N-acetylglucosamine (NAG) molecules are shown at the surface of spike.
