Table 1.
Thermal shift and cell-based antiviral analysis of selected compounds.
| Compound | ΔTm (°C) a | EC50 (µM) b,c |
|---|---|---|
| 5a | 0.18 ± 0.21 | >11 |
| 5b | 1.6 ± 0.19 | >50 |
| 6a | 0.12 ± 0.30 | >33 |
| 6b | 0.10 ± 0.24 | >100 |
| PF74 | 5.7 ± 0.48 | 0.55 ± 0.09 |
a ΔTm: melting point change of CA hexamer in presence of compound compared to DMSO control. Mean ± standard deviation (SD) from at least two independent experiments. b Half maximal effective concentration from at least two independent experiments. c Cytotoxic effects from compounds were visible during EC50 determination; the results may be unreliable.