Table 1.

A summary of the interplays between endocrine-disrupting chemicals (EDCs), AHR signaling, epidemiological reports, and relevant findings on the roles of these EDC-mediated AHR signaling regulations in the development of pancreatic diseases and cancer. References are indicated as [ ].

EDC	Regulation of AHR Signaling	Epidemiological Studies Relevant to Pancreatic Diseases or Cancer	Mechanistic Role of AHR in Pancreatic Diseases and Cancer
Dioxin and dioxin-like compounds	AHR agonists [60,61,62]	See 5. Roles of EDC–AHR Interactions in the Pathogenesis of Pancreatic Diseases and Cancer	See 5. Roles of EDC–AHR Interactions in the Pathogenesis of Pancreatic Diseases and Cancer
Polycyclic aromatic hydrocarbons	AHR agonists and oxidative stress inducers [73,74,75,76,77,78,79,80]	[81,82,83]	Unknown
Hexachlorobenzene	Weak AHR agonist [86]	[87,88,89]	Unknown
Bisphenol A	Weak AHR agonist [101,102,103,104]	[94,95,96,97,98,99,100]	Unknown
Heavy metals	AHR agonists and oxidative stress inducers [109,110,111,112,113,114]	[115,116,117]	Unknown