Figure 3.

CD68 in crescentic experimental rat models: Section shows cellular crescent in a glomerulus from experimental rat models with prominent extra capillary proliferation in the Bowman’s space, partially obliterating the glomerular tuft (left—Hematoxylin and Eosin stain, ×400). Section on the right pane highlights CD68-positive macrophages in the glomeruli from the crescentic glomerulonephritis in rat model (right—diaminobenzidine stain, immunohistochemistry with CD68, ×200). Crescentic glomerulonephritis indicates a severe acute form of glomerulonephritis and the image highlights strong CD68-positive macrophage infiltration in both intra-glomerular as well as extra-capillary crescentic proliferation in our experimental rat model studies. Higher expression of CD68 in crescentic glomerulonephritis was correlated with rapid decline in renal function and higher degree of proteinuria.