FIG. 2.

Systemic administration of CTLA4Ig inhibits MAIDS-associated lymphoproliferation. Each column represents the mean SP weight ± the standard error of the mean for each experimental group. The number of infected mice studied at each time point is indicated at the top of the corresponding column. Administration of CTLA4Ig to uninfected controls did not induce any variation in SP weight. In infected animals, CTLA4Ig administration delayed the onset of the lymphoproliferative process and significantly reduced its amplitude. Statistical significance of the differences between untreated and treated, infected groups was tested by a two-tailed Student t test or the Mann-Whitney test. ∗, P < 0.05; ∗∗, P < 0.025.