Skip to main content
. 2024 Apr 3;25(7):3976. doi: 10.3390/ijms25073976

Figure 3.

Figure 3

Subcellular localisation of B7-H3 in QFU cohort. (a) Representative immunohistochemistry images highlighting membrane (memb), cytoplasmic (cyto), and cytoplasmic + membrane (C+M) B7-H3 expression. B7-H3 expression localised in membrane, cytoplasm, or both (C+M) (24.3%, 24.9%, and 50.9% respectively). (b) Chi-square analysis of the proportion of breast cancer cases with membrane (memb), cytoplasmic (cyto), and cytoplasmic + membrane (C+M) B7-H3 expression by tumour grade and (c) breast cancer subtypes (ER+, HER2+, TNBC; right). KM analysis of (d) all tumours, (e) tumour grade 1 and 2, and (f) Grade 3, stratified by B7-H3 membrane vs. all cytoplasmic expression and BCSS. KM analysis of breast cancer subtype ER+ (g), HER2+ (h), and TNBC (i) stratified by B7-H3 membrane vs. cytoplasmic expression and BCSS. BC, breast cancer; BCSS, breast cancer specific survival; cyto, cytoplasmic; C+M, cytoplasmic + membrane; ER+, oestrogen receptor positive; HER2+, human epidermal growth factor receptor 2; memb, membrane; TNBC, triple negative breast cancer. Scale bar = 60 µm.