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. 2024 Apr 3;25(7):3976. doi: 10.3390/ijms25073976

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© 2024 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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B7-H3 staining in breast tumours in the QBBM cohort. (a) Representative immunohistochemistry images of matched breast tumour and brain metastasis for B7-H3 staining. (b) Chi-square analysis of the proportion of matched breast cancer and BrM cases with positive and negative B7-H3 expression. (c) Chi-square analysis of proportions of matched breast cancer and BrM cases stratified by B7-H3 staining compared across BC subtypes (ER+, HER2+, and TNBC). (d–k) KM analysis of B7-H3 expression and BCSS cases compared across all tumours (d), ER+ (f), HER2+ (h), and TNBC (j). KM analysis of B7-H3 expression and BrMSS cases compared across all tumours (e), ER+ (g), HER2+ (i), and TNBC (k). Note the X axis changes between breast cancer and BrM. BC, breast cancer; BrM, brain metastasis; HER2+, human epidermal growth factor receptor 2; ER+, oestrogen receptor; KM, Kaplan–Meier; TNBC, triple negative breast cancer. Scale bar: core = 200 µm; inset 60 µm.