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. 2024 Apr 8;14:21–31. doi: 10.2147/DNND.S444567

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© 2024 Duan et al.

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The difference of exosomal microRNA level different age group of ND with t-tests or among EOAD, LOAD and ND are compared with nonparametric tests (Kruskal–Wallis test). (A) There are no significant difference in age<65 years old group and age ≥65 years old group of exosomal microRNA (B). Comparing with ND, the expression of miR-125b-1-3p in serum exosomes of LOAD is upregulated significantly(p < 0.001). (C) There are no significant difference of miR-193a-5p among EOAD, LOAD and ND. (D) Comparing with ND, the expression of miR-378a-3p of EOAD and LOAD are upregulated significantly(p < 0.001 and p = 0.013, respectively).(E)Comparing with EOAD, the expression of miR-378i of LOAD and ND are downregulated significantly(p = 0.004 and p = 0.039, respectively) (F). Comparing with ND, the expression of miR-451a of LOAD is upregulated significantly(p = 0.001). The y-axis indicate microRNA expression levels by log10 change. *p < 0.05; **p < 0.01;***p < 0.001.