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. 2024 Apr 8;14:21–31. doi: 10.2147/DNND.S444567

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© 2024 Duan et al.

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Exosomal microRNAs qRT-PCR (A) The difference of exosomal microRNA level between AD and ND is compared with nonparametric tests Mann–Whitney U-test. The y-axis indicates microRNA expression levels by log10 change. *p < 0.05,***p < 0.001. The expression of miR-125b-1-3p in serum exosomes of AD is upregulated significantly(p < 0.001);The exosomal miR-193a-5p of AD is downregulated significantly comparing with ND(p=0.020); The expression of miR-378a-3p in serum exosomes of AD is upregulated significantly(p < 0.001); Comparing with ND, the expression of exosomal miR-378i of AD is downregulated significantly(p = 0.042);The expression of miR-451a in exosomes of AD is upregulated significantly (p< 0.001) (B). The receiver operating characteristic(ROC) curve of serum exosomal miR-125b-1-3p. Area Under the Curve(AUC) of miR-125b-1-3p is 0.765 to distinguish AD from normal with a sensitivity and specificity of 82.1% and 67.7% (C). The ROC curve of serum exosomal miR-451a. AUC of miR-451a is 0.728 to distinguish AD from ND with a sensitivity and specificity of 67.9% and 72.6%,respectively.